Saturday's game marks the 65th meeting between Tennessee and Ole Miss (UT leads series, 44-19-1).
The Vols won the last meeting between the two schools, a 52-14 victory in Knoxville on Nov. 13, 2010.
Despite the series beginning in 1902, this week's game marks the fifth time UT has made the trip to Oxford (2009, 2004, 1988, 1951), the Vols are 3-1 in those games.
The Vols lost in their last trip to Oxford, a 42-17 loss in 2009. Tennessee had previously won a series high-tying 12 consecutive games over Ole Miss from 1984-2005.
Ole Miss is ranked entering a game vs. Tennessee for the first time since 1990.
Since losing eight in a row to Ole Miss from 1959-66, UT is 21-8 in the series.
Vols are seeking first win vs. a Top 3 team since beating #3 Georgia 19-14 in Athens (10/9/04).