Holdsclaw had a legendary career at the University of Tennessee where she was a four-time Kodak All-American. She finished her collegiate career with 3,025 points and 1,295 rebounds, making her the all-time leading scoring and rebounder in school history (mens and womens), the all-time leading scorer and rebounder in SEC women's history, and the all-time leading scorer and rebounder in the history of the NCAA Womens Tournament. Holdsclaw won the Naismith player of the year trophy twice (1998 and 1999) and posted a 134-17 win/loss record during her remarkable career as a Lady Vol. In 2000, she was named Naismith's Player of the Century for the 1990s.