Ye Olde Steakhouse is a long-time local favorite -- it just recently reopened in the original location after a 2 year stint at L&N while undergoing fire-damage repairs.
Regas and the Orangery are oldies, but goodies (bring your wallet to the Orange) -- lots of history and personality to both.
If you're looking for something new -- try Conner's or Edison Park in West Knoxville, or Riverside Tavern on Volunteer Landing. Good sushi can be found at Nama downtown or Wasabi out west.