Oregon's defense looks terrible. I think Sampson could eclipse 200+ yards on them if he was given the greenlight. But we would probabky be more balanced if we played them. But he is certainly capable.
Honestly, all these Big 10 defenses get overrated every year becuase the offenses in that league usually underwhelm and as a result the defensive stats look good. But, just like Nico and our 3rd string WRs put up 35 against Iowa's caunted defense, I think our offense would walk down the field against these Big 10 defenses.