Who's run heavy right now really? At least in a traditional sense.
UGA? Everyone else uses various spread and rpo concepts to get guys in space..
I think you definitely need a really solid 3 down linemen... But with the way teams put players in space, you need to cover ground in a hurry and close gaps.
Outside a couple teams like bama, aTm and UGA that will give anyone matchup problems with thier RBS size/speed... Be fast, and be great tacklers...
Nickel formations are so common theses days; I think the days of declaring 43, 34 etc are numbered...
But yeah depending on personnel, there's a handful of teams that will be matchup problems.. But those are usually the teams that are problems for everyone they play..Jmo