Fellow San Antonian here(transplant), since 1982. I have been a vol fan for 68 years. Are your plans to fly or drive? If driving it will be a hard 2-day drive. If you plan on flying, I suggest you fly to Nashville, then rent a car to drive to Knoxville. The drive from Nashville to Knoxville is very pleasant and will only take a little over a couple hours through the Smoky Mtns. If you have any Alabama gear... burn it before you enter Neyland Stadium. lol.
Just clarification, the drive from Nashville to Knoxville does not go through the Smoky’s. But it is a nice little drive.