This is extremely forward to say for making the comparison, but not gonna lie, If F.U.N. doesn't end out being my generation's Queen with their lead singer as good as he is then they have failed miserably at their potential.
I love RunDMC's version of Walk This Way but isn't it really just a cover song with samples. I know Aerosmith appeared in the video but that was more of an acknowledgement to them writing the song than an collaborative effort.
On a side note if you've ever seen a behind the scenes clip of Run DMC talking about that track they initially hated the idea. Rick Reuben had to convince them to do it.