I would go with Calvin Johnson. He is a beast at 6'4, 225 lbs., and 4.4 speed. Not to mention his huge vertical (I can't remember what exactly it is). He put up great numbers at Tech with double coverage and an average at best QB.
AP is getting a lot of love in this thread, but I just don't see him as a superstar in the NFL. He reminds me a lot of Chris Brown. He runs upright a lot and has big durability concerns. While he will be a better pro than Brown, I still don't think he is worth the #1 pick.
And call me crazy, but I think Quinn will be a bust in the NFL. As soon as Weis went to ND, Quinn became the "next Tom Brady". I just don't see it. Yeah, he makes some great throws at times; but I also have seen a ton of throws that just make you say "What the...?".