I'd like to scale back a bit on the discussion in order for it to take on different possibilities.
Space is absolutely the biggest imaginable thing...
Let's discuss some options:
1) World Peace is finally reached. Human's harness all the power of Earth, and stay content just living in the paradise that it has become again. 45,000 CE Humans have not evolved hardly at all because they reached a balance with the planet. Population has leveled out to around 200,000,000,000 people for the past 1,000 years. People are living on every continent, living underground, and even in the ocean (underwater). The dead become one with the Earth Flame, and are directly recycled back into the magama. People take "release" potion when their old age begins to hurt their bodies. But for most of the 150 years they live (on average), they are extremely happy and have seen much of planet Earth, while having lived on every continent at least once for a short time. They admire the beautiful stars in the night skies everywhere, and believe letting go of the notion to travel to them was the key to their inner peace. (Because they are simply too far away).
2) The year is 83,451 A.S.E. (After Solar Explosion). Earth's sun exploded the year 3476 CE after a human generated event horizon destabilized the nuclear fusion process. Mankind at that point had colonized all of their solar system and had even mastered bending space time to travel beyond the barrier of "light speed". However, The Sun was the center focal point of their travel network and without it, humans no longer had a directional beacon to map their vast civilization or to return HOME.
83,000 years later only .001 % of the worlds that humans had colonized still have any memory of their true origin as a species.
On one world mankind has evolved to breathe in their planets' oceans. Another planet - humans have returned to a nomadic existence running to far off lands over and over again to escape the savage blood thirsty giants that seek to rip them apart every 10 years that they awake from their frozen slumber. In the Sirius constellation, humans died 60,000 years ago and their organic matter is now utilized to fuel "hot wavy light" for a primitive species trying to stay warm on the dark side of tidal locked world from the star Sirius B. Closer to home...Pluto is the only planet to have survived "SE" and now dwells where the gravitational pull of the Sun once was 83,451 years ago.
However, 545 years A.S.E.- a small group of human scientists blended with their hyper-evolution technology. This technology allowed humans to adapt to any worlds natural conditions and survive. It also allowed them to access any memory locked into the DNA code of humans. 82,000 years later these humans are no longer just flesh and blood. They are Immortal Super Beings that can see across time and space while wielding the power of the stars from their own hands. They now travel and seed life on millions of worlds. They are the centerpiece of various aliens beliefs of good and evil. Beginning and End. They are the only creatures that remember that Earth ever existed...
3) 2613 CE, Mars has become a breeding ground for humans used for free labor on the asteroid belt.
They grow weary and launch secret plan to destroy Earth via asteroid collision. It works! The Earth is decimated by asteroids and all complex life goes extinct. However, Mars also is destroyed in the process.
In Conclusion- If there's even a .001 % chance that mankind will harness the very Universe one day..then I'm all for it!