I did an insane league this year.
2 QB
2 RB
2 WR
1 TE
1 Flex
1 K
2 DL
2 LB
2 DB
15 BN spots
Never did a league this big with defensive players, but we wanted to go big.
I think I turned out pretty well:
QB (Dak Prescott, Ryan Tannehill, Jameis Winston, Deshaun Watson, Mac Jones)
RB: (Alvin Kamara, Aaron Jones, Clyde Edwards-Helaire, Myles Gaskins, Chase Edmonds, Nyheim Hines)
WR: (Calvin Ridley, Julio Jones, Deebo Samuel, Corey Davis, Laviska Shenault, Jaylen Waddle, Cole Beasley)
TE: (Kyle Pitts, Hunter Henry, Rob Gronkowski)
K (Jason Sanders)
I won't list my defensive players, because nobody cares. But I carefully constructed my roster so that I had a definite 3 players at each position (except for Kickers), and gave myself some serious flexibility. I don't know if Winston will be horrible in NO, but I would assume he would be better. I don't know if Watson will play, but I'm not harmed by keeping him. If he plays, I get a Top 5 QB. If he doesn't, well, big deal. Hoarding QBs isn't a bad idea in a 2 QB league.
RBs....I had the last pick in the first round, the dude in front of me picked Najee Harris, so Kamara fell to me, and then I instantly got Aaron Jones to follow up. Felt good about that.
Took forever to draft all 30 spots, but man, it was fun.