Random, but I always think of the Louisville game with Darius's free throws.
And the "choke that never was" was pretty relevant as well.
seriously guys, win against Florida in 2008 was huge because of what it meant and nobody is even paying attention to it. Definitely bigger than the other Florida wins, bigger than the Kansas win, etc.
UT Memphis game was big game. I beg to differ that is was the "biggest game in recent history" for the Tigers. These were bigger:
2007 Georgetown win (double digit win against Top 4 team on national TV and current attendance record for FEF).
2007 OSU loss E8
2007 Texas A&M win S16
2006 UCLA loss E8
2005 UCLA win
2005 Duke loss
I like the OP's list quite a bit.
For honorable mentions, I have seen a lot of love tossed in the direction of the '07 Memphis game where Lofton just went nuts at TBA. That was a fun one.
The GTown game was big but the rest were not that big of games due to the outcomes. Had any of those Elite Eight games been wins then I could understand. UTK vs UM in 2008 was the first time in a long time, if not the first ever, meeting between #1 and #2 teams from the same state sans North Carolina. It was the biggest game of the regular season and involved this state. Memphis was undefeated and UTK had only one loss at the time (Texas?). Say what you will but I disagree.
An E8 game, regardless of outcome, is always bigger than a regular season game because there is more at stake.
All that happened as a result of this "monster game in February of 08" was Memphis was a #1 seed, UT a two. Memphis goes on to play for NC, UT gets run by Louisville in S16.
On the same note, Florida fans don't care about any of the UT losses during their back to back NC years.