This study is a great example of how bad some of these clinical trials that claim ivermectin works actually are. For example
1. this is a poorly designed study that as a prophylaxis study doesn’t report things like risk of exposure, adherence to medication, time from treatment to exposure and other things you want to see in a clinical trial looking at a prophylaxis.
2. How they conducted propensity matching is kinda screwed up. Highly doubt they got that many people to match based on criteria they give
3.treatment with ivermectin was actually prevented once someone got covid yet they are reporting outcomes with treatment. It was allowed in the control group and about 80% died who were hospitalized. Strange.
4. Authors kept on changing their paper multiple times until published. Infection rates jumped from 9% to 44% after deciding to add a few hundred people to the study. Definitely a red flag. Can see the original paper here.
(PDF) Ivermectin Prophylaxis Used for COVID-19 Reduces COVID-19 Infection and Mortality Rates: A City-Wide, Prospective Observational Study of 223,128 Subjects Using Propensity Score Matching.
5. authors report they receive salaries from a drug company that make ivermectin but state that this isn’t a conflict of interest.
6. one of the authors is under investigation in brazil for killing people in a clinical trial.
Covid-19: Trial of experimental “covid cure” is among worst medical ethics violations in Brazil’s history, says regulator
7. But what really confirms this is a fraudulent study is a news report from the mayor’s office during the study reports only a little more than 8000 people actually ended up picking up their ivermectin after 1.5 months.
Nota de esclarecimento tratamentos profiláticos | Município de Itajaí
“138216 residents took the first dose. Fifteen days later that number dropped to 93970 people who took the second and third doses. Subsequently, only 8,312 people withdrew the fourth and fifth doses. That is there was no biweekly continuity of the use of ivermectin, as recommended”
Sadly there are some doctors out there that will use this to convince people that ivermectin is a miracle cure when this study does not actually address treatment and the conduct of the study is so problematic.
If you are interested in ivermectin as a clinical trial the activ-6 trial is still recruiting. Will ship med to your home free.