Yes. There is real harm being done to real people. For example, a friend of mine has a son battling brain cancer. He was just approved for an experimental treatment at a health center with government funding contracts in place. When Trump issued an EO last week which touched on medical research, communication with the care team impacted and that child's plan of care was thrown into disarray.
One of the problems is that all of the programs that almost most Americans find "worthy" is co-mingled with the programs that are, shall we say "questionable." For instance, how does one unpack the true humanitarian aid provided by USAID (say, Earthquake relief operations in Turkey) from the social engineering programs (Sesame Street in Iraq, anyone?)
Marco Rubio says that preliminary inquiries were made into USAID programs so the Admin could determine how to proceed. He also says those inquiries were stonewalled. That, in turn, led to the complete disruption of ALL programs because ALL funding was halted in order to stop fraud/programs not supported by this Admin.
Assuming Rubio was correct, this seems to be an instance of entrenched bureaucracy thinking this Administration was more of the same, when it is not. Some of the hurt being experienced may have been avoided but for agency lack of cooperation with the Administration. As much as I hope this Admin will cut wasteful spending, I hope we can at least get back to quickly funding things that the vast majority of Americans think are worthy of funding.