Selling out is only used when the % is near 100%. It's not a good idea. To stop a good player that uses a run heavy offense, you need to learn run fits of the different coverage shells. You can display the run gaps each player is assigned by holding L2+R2 and then circle or square. The same way you do in Madden even though you guys won't admit it's a carbon copy.
My personal advice, don't use blitz plays to stop the run. The best generic run defense is cover 4 quarters (not from pass defense formations, my favorite is 3-4) with the safeties moved down manually and good user gap control. It's quite easy when you learn what gap your player needs to fill and shoot it and let your safeties clean up. You'll notice that quarters defense is one of the few plays that have both the safeties playing run fits, which means, if it's a handoff their animation steps toward the los and abandons their zone animation. That's a basic explanation.
Ps. I only pass commit on long yardage plays unless the player never runs. Pass commit audible will take away the run fits of your coverage meaning the animation will remain a zone animation until the runner breaks the LOS. This is not real football, it's an animation based video game with triggers for animation. It has the exact same triggers as current Madden.