Nobody's disputing that the ancient Greeks, the Golden Horde, the Ottomans and others hadn't lived on the land where Odessa was eventually built. Most people recognize that. But the city of Odessa was, in fact, built and founded by the Russians, the same way Knoxville was built by and founded by Americans regardless of the native peoples who lived there before us who we forcibly removed through genocide and other methods of ethnic cleansing.
This was Odessa in 1794:
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This was Odessa in 1814:
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There's no way Jews are the biggest minority in Odessa. Your information is very out of date as that hasn't been true for nearly a century. In the late 19th and early 20th centuries, Russians and Jews co-existed and the population of Jews even became larger than the population of Russians by 1939. WWII changed that, in no small part because of the Romanians and the Ukrainian nationalists who allied themselves with Nazi Germany. And the apples haven't fallen far from the tree.
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Odessa was under Romanian control when WWII began and the Romanians took part in the Holocaust, ethnically cleansing Odessa of its Jewish population.
1941 Odessa massacre - Wikipedia
At the same time, in Lviv and throughout the region, Ukrainian nationalists were also carrying out the Holocaust against Jews.
Lviv pogroms (1941) - Wikipedia
Even these days, Jews aren't truly accepted in Ukraine because of Ukrainian nationalists.
Ukrainian marchers in Kiev chant ‘Jews out’ | The Times of Israel
The chart above clearly shows that the Russian percentage of Odessa's population peaked during the Russia Imperial era and actually fell during the Soviet era, and that's why I keep saying the claim that the USSR planted a lot of Russian squatters in the region is bogus. Russians were already there long before the USSR was even established.