Here is what I found online from websites discussing airport safety and pilot confessionals:
Ronald Reagan Washington National Airport (Washington, D.C.)
Challenges: While passengers get a great view of national monuments like the White House and
the Pentagon during landing, pilots must dodge several no-fly zones located over D.C. and
navigate a “River Visual” approach requiring a 30 to 40 degree turn close to the Potomac River to
line up with the runway.
San Diego Airport, California
Pilots have to be especially skilled to fly into this busy airport that is surrounded by mountains and strong tailwinds blowing in from the west. On September 25, 1978, a Boeing 727-200 collided in mid-air with a Cessna 172 while attempting to land at San Diego Airport. All 137 passengers were killed along with 7 people on the ground.
LaGuardia Airport (Queens, New York)
Challenges: Though scheduled flights are limited to 1,500 miles, except for Denver and Saturday
flights, LaGuardia's popular location creates a difficult and busy approach for pilots navigating
multiple runways and jets landing in New York.
San Francisco
SFO is very safe. The reality is SFO has dual closely spaced parallel runways that cross. Those controllers do an amazing job in keeping traffic moving and seldom miss a beat. Is it complex, you bet your butt it is complex and not every controller is cut out to succeed at SFO or similar designed airports with that traffic that SFO handles.