When you say disagree with their lifestyle, what do you mean specifically? I don't want to get my nuts chopped off and grow tits, does that mean I disagree with their lifestyle? They can do whatever they want as long as it doesn't affect me. I think this is the main point of contention that I tend to see being misconstrued. A bunch of people up in arms say "i don't care as long as I'm not forced to be a part of it!/they don't shove it down my throat!" Or something like that.
I am not bothered by seeing a trans person walking down the street, or in my workplace, or on tv, or in an article. Change the channel. Don't read the article. Be a decent human being. I am also not bothered by doing a kindness to someone by referring to them by their preferred name, unless they are major assholes, then I'll call them whatever I want.
Are there extreme examples of people that take acceptance way too far? Getting into random people's faces, screaming at people because of simple mistakes? Sure, and I look at them with the same bewilderment and disappointment as I do the ones who are screaming about things being shoved down their throat but often could not defend that statement without sounding pitiful. Both seem like whiney bitches.