Of those listed, I would say Patterson. His defense scheme of choice is a 4-2-5. He had this to say about how you adapt to the personnel year in and year out (per Football Scoop):
In 2000, we had 10 NFL guys and we hardly blitzed at all, playing base defense and only blitzed 6 percent of the time. In 2002, our personnel was different and we man-blitzed 43 percent of the time. In 2008, we were a zone-blitz, two shell team, that's what we did the best. In 2009, we were a four-man rush team because we could run. In 2010, 50 percent of the time we held offenses to three and out. When you get teams down to six possessions you're going to have a chance to win. You just have to find what you're good at.
Last year we weren't very good in red-zone defense. The key was, teams didn't get there, so it didn't make any difference. Our whole thing comes down to how many touchdown passes do you give up in a year. We want to average one a game. The last three years we've allowed eight, 10 and 10. We're going to have people in the box to stop the run. Stopping the run and don't give up big touchdown passes, don't give up the big play.
It's one thing to say you can make the adjustments, another to do it. But he has backed it up year in and year out.
On the down side the are 6-4 thus far in the first season in the Big 12 and will be underdogs against Texas and Oklahoma.